Patient Profiles

Profile of a Patient With ABSSSI (Cutaneous Abscess From Skin Irritation)

Not an actual patient

ABSSSI Cutaneous Abscess: Skin Irritation

Patients like Jason may be considered an appropriate candidate for SIVEXTRO 

Patient With ABSSSI, Cutaneous Abscess Skin Irritation on the Back

Jason is a 47-year-old male warehouse worker who recently developed swelling, redness, and tenderness on the left side of his back, and subsequently a fever in the past 24 hours. It has been getting worse for days, and he suspects it’s from wearing a poorly fitted back brace at work that irritated his skin.

Reported Signs and Symptoms:
  • On his back: swelling, redness, and pain
Other Medical Factors:
  • Hyperlipidemia
Clinical Examination:
  • BMI of 28.1 kg/m2
  • Vital Signs: Temp: 99.8°F; RR: 16 RPM; HR: 120 BPM; BP: 120/80 mm Hg
  • On left side of his back: 3 cm tender, firm to slightly fluctuant mass; ~188 cm2 area of regional erythema
  • Mild tenderness on palpation
Lab Results:
  • WBC: 12 500 x 103 cells/mL

Diagnosis: ABSSSI (cutaneous abscess)

Next Steps:
  • Initiate empiric antimicrobial therapy
  • Incision and drainage

ABSSSI, acute bacterial skin and skin structure infections

BMI, body mass index

BP, blood pressure

BPM, beats per minute

HR, heart rate

RR, respiratory rate

RPM, respirations per minute

WBC, white blood cells


SIVEXTRO is an oxazolidinone-class antibacterial indicated in adults and pediatric patients 12 years of age and older for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-susceptible [MSSA] isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus group (including Streptococcus anginosus, Streptococcus intermedius and Streptococcus constellatus), and Enterococcus faecalis.


To reduce the development of drug-resistant bacteria and maintain the effectiveness of SIVEXTRO and other antibacterial drugs, SIVEXTRO should be used only to treat ABSSSI that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Selected Safety Information

Patients with neutropenia: The safety and efficacy of SIVEXTRO in patients with neutropenia (neutrophil counts <1000 cells/mm³) have not been adequately evaluated. In an animal model of infection, the antibacterial activity of SIVEXTRO was reduced in the absence of granulocytes. Alternative therapies should be considered when treating patients with neutropenia.

Clostridioides difficile–associated diarrhea (CDAD), ranging from mild diarrhea to fatal colitis, has been reported with nearly all systemic antibacterial agents, including SIVEXTRO. Evaluate all patients who present with diarrhea following antibacterial drug use. Careful medical history is necessary because CDAD has been reported to occur more than two months after the administration of antibacterial agents. If CDAD is suspected or confirmed, antibacterial use not directed against C. difficile should be discontinued, if possible.

Development of drug-resistant bacteria: Prescribing SIVEXTRO in the absence of a proven or strongly suspected bacterial infection or prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Adverse reactions: The most common adverse reactions (≥2%) in adults for SIVEXTRO are nausea (7%), headache (5%), diarrhea (4%), vomiting (3%), and dizziness (2%). 

In adult patients receiving SIVEXTRO intravenously, infusion- or injection-related adverse reactions including but not limited to: phlebitis, injection- or infusion-site pain or swelling, injection-site reaction, erythema, or induration, and infusion-related reaction occurred (4%). 

The most common adverse reactions (>2%) in pediatric patients 12 years of age and older are phlebitis (3%) and increased hepatic transaminases (3%).

Drug interactions with BCRP substrates: SIVEXTRO (when administered orally) can increase the plasma concentrations of orally administered Breast Cancer Resistance Protein (BCRP) substrates and the potential for adverse reactions. Monitor for adverse reactions related to the concomitant BCRP substrates if coadministration cannot be avoided.

Before prescribing SIVEXTRO, please read the accompanying Prescribing Information. The Patient Information also is available.